Rapid chiral assembly of rigid DNA building blocks for molecular nanofabrication |
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Authors: | Goodman R P Schaap I A T Tardin C F Erben C M Berry R M Schmidt C F Turberfield A J |
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Affiliation: | Clarendon Laboratory, Department of Physics, University of Oxford, Parks Road, Oxford OX1 3PU, UK. |
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Abstract: | Practical components for three-dimensional molecular nanofabrication must be simple to produce, stereopure, rigid, and adaptable. We report a family of DNA tetrahedra, less than 10 nanometers on a side, that can self-assemble in seconds with near-quantitative yield of one diastereomer. They can be connected by programmable DNA linkers. Their triangulated architecture confers structural stability; by compressing a DNA tetrahedron with an atomic force microscope, we have measured the axial compressibility of DNA and observed the buckling of the double helix under high loads. |
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