犬的免疫介导疾病的诊断和治疗

我们经常能看到一些犬表现出干燥和皮屑剥落的皮肤,变薄变稀的皮毛,泪流不止,足部过度舔,慢性腹泻,多动,不能长胖或情绪波动.这些症状最常见的诊断是跳蚤过敏性皮炎,环境过敏或饮食中缺乏脂肪酸.通常多作为治疗皮肤疾病的原因前往看兽医.然而,所有这些症状往往指向一种免疫介导缺陷的障碍—不活跃的免疫系统（免疫缺陷）,或过度活跃的免疫系统（自身免疫性疾病）.繁育者将带有隐蔽免疫介导缺陷的犬用于育种繁殖,将带来一些亚临床性质的问题.而一些兽医对此类问题的出现并不很了解,忽略了涉及免疫系统的缺陷和自身免疫性疾病的对症治疗.本文提供了先天的和适应性免疫的实际概述,并介绍这些宿主的防御机制是如何涉及健康和疾病的.

Diagnosis and Treatment of Canine Immune Mediated Disease

We can usually see some dogs exhibiting dry flaking skin, thinning coats, teary eyes, excessive foot licking, chron- ic diarrhea, hyperactivity, inability to gain weight or mood swings. The most common diagnoses for these symptoms are flea al- lergies dermatitis, environmental allergies or lack of fatty acids in the diet. Treating skin disorders is the most frequent reason for trips to the veterinarian. However, all these symptoms often point to another disorder-either an under active immune system （immunologic deficiency）,or an overactive immune system （autoimmune disease）. Breeders with Dog that hidden immune-me- diated defects used for breeding will bring the problem of some second clinical properties. But some vets＇ to the emergence of these problems is not understanding, ignoring the involving the immune system defects and autoimmune diseases symptomatic treatment. This paper provides practical overview of both innate and adaptive immunity, and introduction of how the host＇s de- fense mechanisms involved in health and disease.