Epidemiology, clinical signs, histopathology and molecular characterization of canine leproid granuloma: a retrospective study of cases from Brazil |
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Authors: | Conceição Lissandro Gonçalves Acha Livia Maria Rosa Borges Alexandre Secorun Assis Fernanda G Loures Fabricia Hallack Fonseca e Silva Fabyano |
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Institution: | 1. Departamento de Veterinária, Universidade Federal de Vi?osa, Vi?osa, Minas Gerais, Brazil;2. Clinica Veterinária S?o Francisco de Assis, Muriaé, Minas Gerais, Brazil;3. Universidade Estadual Paulista, Faculdade de Medicina Veterinária e Zootecnia, Botucatu, S?o Paulo, Brazil;4. Diagnóstico em Dermatopatologia Veterinária, Condomínio Bosque Acamari, 126, Vi?osa, Minas Gerais, Brazil;5. Departamento de Bioestatísca, Universidade Federal de Vi?osa, Vi?osa, Minas Gerais, Brazil |
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Abstract: | Thirty-eight cases of canine leproid granuloma were diagnosed between 2000 and 2008. Diagnosis was based upon clinical and histopathological findings and the presence of acid-fast bacilli in skin sections. The clinical lesions were localized predominantly on the pinnae and included papules, plaques and nodules, with or without ulceration. Boxer dogs were the breed most affected. Histopathological findings included nodular to diffuse pyogranulomatous, lymphoplasmocytic inflammatory infiltrates, with or without necrosis, localized in the dermis or subcutaneous tissue. The bacillary loading and morphology were variable among the lesions analysed. There was no significant correlation between bacterial load and histopathological pattern, dominant type of inflammatory infiltration or the amount of necrosis or giant cells. No correlation was observed between giant cells and histopathological pattern. In the majority of cases where a PCR-based assay was done, a novel mycobacterium species as the main aetiological agent was identified, as reported in previous studies. |
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