| 醋氨己酸锌的大鼠长期毒性实验研究 |
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| 引用本文： | 潘榆玲,徐伟,袁惠南.醋氨己酸锌的大鼠长期毒性实验研究[J].湛江医学院学报,1993(4). |
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| 作者姓名： | 潘榆玲 徐伟 袁惠南 |
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| 作者单位： | 中国药品生物制品检定所，中国药品生物制品检定所，中国药品生物制品检定所 广东医学院第二附属医院，广东医学院药理学教研室 |
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| 摘 要： | 以大鼠80只,随机分4组(每组20只,简称A,B,C,D组),前3组分别用醋氨己酸锌225,450,900mg/kg·d连续口饲12周,各剂量组大鼠一般行为正常。体重、血常规、凝血时间、血小板计数,血液生化学指标:谷丙转氨酶(GPT)、谷草转氨酶(GOT)、碱性磷酸酶(AKP)、总蛋白(TP)、白蛋白(ALB)、血糖(GLU)、总胆红素(TBili)、尿素氮(BUN)、肌酐(Cree)、总胆固醇(TC-holes)与对照组(D组)相比无明显差异(P>0.05),病理解剖检查也未见异常。
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| 关 键 词： | 大鼠 醋氨己酸锌 毒性测定 动物+实验 |
LONG-TERM TOXICITY STUDY OF ZINC ACEXAMATE IN RATS |
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| Pan Yulin Xu Wei Yuan Huinan,National Institute for The Control of Pharmaceutical and Biological Products.LONG-TERM TOXICITY STUDY OF ZINC ACEXAMATE IN RATS[J].Journal of Guangdong Medical College,1993(4). |
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| Authors: | Pan Yulin Xu Wei Yuan Huinan National Institute for The Control of Pharmaceutical and Biological Products |
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| Institution: | Pan Yulin Xu Wei Yuan Huinan
National Institute for The Control of Pharmaceutical and Biological Products |
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| Abstract: | In these experiments ,3 groups of 20 rats were given orally zinc acexamate(225 ,450,900mg/ kg. d respectively)for 12 weeks. The significant changes were not found between zinc acexamate
-treated groups and control group in the behaviour,the body weight,the routine examination of
blood,the time of blood coagulation,the number of blood platelet,biochemical examination of blood,
and pathological anatomy. |
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| Keywords: | rat zinc acexamate toxicity test animals experiment |
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