胰淀素调控生理机能的研究进展

胰淀素(Amylin)在机体能量代谢平衡过程中具有重要作用,通过兴奋机体饱食中枢来抑制动物摄食,Amylin的受体广泛分布于第四脑室底部最后区(AP),当受体被激活后,神经信号会通过孤束核(NTS)传至前脑,同时还可通过外侧旁核(LPBN)传至下丘脑外侧区(LHA)及下丘脑其他神经核团,Amylin信号传递必须经过NTS和LPBN,此外,Amylin也是机体发生肥胖的重要信号,肥胖动物机体Amylin的血浆浓度较正常动物显著升高,脑室注射Amylin能引起体重明显降低,而注射Amylin受体的抑制剂则使体重明显上升继而引发肥胖。Amylin是一个潜在治疗肥胖的作用靶点,本文就Amylin在调节动物摄食和能量代谢中的作用进行综述。

Research Progress on Amylin Control Physiological Functions

Amylin is an important player in the balance of energy metabolism. Amylin reduces eating via a meal size effect by promoting meal-ending satiation. This effect seems to depend on a direct action in the area postrema(AP), which is an area rich in amylin receptors. Subsequent to the activation of AP neurons, the neural signal is conveyed to the forebrain via relays involving the nucleus of the solitary tract(NTS) and the lateral parabrachial nucleus(LPBN) to the lateral hypothalamic area(LHA) and other hypothalamic nuclei. While the NTS and LPBN seem to be necessary for amylin's eating inhibitory effect, the role of the LHA has not yet been fully investigated. Amylin may also act as anadiposity signal. Plasma levels of amylin are higher in obese individuals, and chronic infusion of amylin into the brain reduces body weight gain and adiposity; chronic infusion of an amylin receptor antagonist into the brain increases body adiposity. Therefore, amylin is a potential target for the treatment of obesity. In this paper, the progress on the study of energy metabolism was reviewed.