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Biosynthesis of C4 (fourth component of complement) by hybrids of C4-deficient guinea pig cells and HeLa cells
Authors:H R Colten  R Parkman
Abstract:Peritoneal exudate cells from guinea pigs homozygous for a genetic deficiency of the fourth component of complement (C4) were fused in vitro with a cell line of human origin (HeLa). The resulting hybrid cells, derived from cell lines each incapable of C4 synthesis by themselves, synthesized functionally active human C4.
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