A cardiac rhabdomyoma in a Guinea pig |
| |
Authors: | Kobayashi Tatsuya Kobayashi Yoshihiko Fukuda Uina Ozeki Yukiko Takahashi Maki Fujioka Shigeru Fuchikami Jun-Ichi |
| |
Institution: | Sugi Institute of Biological Science Co., Ltd., 10221 Kobuchisawa-cho, Hokuto, Yamanashi 408-0044, Japan. |
| |
Abstract: | A guinea pig (9-week-old) that had been placed in a control group for a pharmacological test was found to have a single nodule on the surface of the right ventricular wall. In a transverse section of the heart after fixation, a whitish mass was found that extended from the subendocardium to the subepicardium of the right ventricular wall. Histopathological examination revealed a spongy network consisting of vacuolated spaces in the myocardium of the right ventricle extending to the myocardium and subepicardium of the right atrium. The vacuolated space was PAS-positive. Immunohistochemical examinations revealed that the lesions contained striated fibers that were positive for anti-desmin and anti-myoglobin. Electron micrographs revealed the lesions resulting in affected striated muscle fibers and accumulations of many glycogen granules. Based on the findings, the lesions were diagnosed as a cardiac rhabdomyoma. This is the first report of application of immunohistochemical examinations to diagnosis of cardiac rhabdomyoma in the guinea pig. |
| |
Keywords: | cardiac rhabdomyoma guinea pig histopathology immunohistochemical examination |
本文献已被 PubMed 等数据库收录! |
|