Oxidative metabolism of lindane and its isomers with microsomes from rat liver and house fly abdomen |
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Authors: | Keiji Tanaka Norio Kurihara Minoru Nakajima |
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Institution: | 1. Department of Agricultural Chemistry, Kyoto University, Kyoto, Japan;2. Radioisotope Research Center, Kyoto University, Kyoto, Japan |
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Abstract: | Lindane and other hexachlorocyclohexane isomers produced 2,4,6-trichlorophenol as the major oxidative metabolite when incubated in the presence of NADPH under aerobic condition. A mechanism for the formation of 2,4,6-trichlorophenol is proposed, which includes direct oxygenation of the cyclohexane ring. The proposed mechanism is supported by data from studies of model chemical reactions of the pentachlorocyclohexanol isomers. Pathways leading to 1,2,4-trichlorobenzene, tetrachlorobenzene isomers, 2,4,5-trichlorophenol, and tetrachlorophenol isomers are discussed, and are considered to include the route through pentachlorocyclohexene and hexachlorocyclohexene. Reductive dechlorination of lindane under anaerobic condition was observed using microsomes and NADPH. |
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Keywords: | To whom correspondence should be addressed at the Radioisotope Research Center |
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