| 雌激素受体碘标记放射配体的合成与选择 |
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| 引用本文： | 张丁联,郭韶春,郑嘉庚,袁健健,王斌.雌激素受体碘标记放射配体的合成与选择[J].核农学报,2006,20(3):252-254. |
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| 作者姓名： | 张丁联 郭韶春 郑嘉庚 袁健健 王斌 |
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| 作者单位： | 中国农业科学院原子能利用研究所/中国农业科学院农产品加工研究所/农业部农业核技术与农产品加工重点实验室,北京,100094;北京北方生物技术研究所,北京,100086 |
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| 摘 要： | 雌激素的放射受体分析在药物设计、癌症等疾病的诊断和治疗等方面的应用十分广泛。本研究中,共合成了7种125I标记雌激素放射配体,分别为125I-Estradiol-6-CMO-His1、25I-Estradiol-3-CME-His1、25I-Estradiol-17-HS-His、21-25I-Estradiol、41-25I-Estradiol、2,4-2125I-Estradiol和16α125I-Estradiol,并比较了它们用于放射受体分析(RRA)的结果,表明在上述雌激素放射配体中,16α125I-Estradiol具有较好的生物活性。
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| 关 键 词： | 雌激素受体 放射受体分析 125I放射配体 |
| 文章编号： | 1000-8551(2006)03-252-03 |
| 收稿时间： | 08 16 2005 12:00AM |
| 修稿时间： | 2005年8月16日 |
SYNTHESIS AND COMPARISON OF DIFFERENT ~(125)I-ESTRADIOL ANALOGE FOR ESTROGEN RADIO RECEPTOR ASSAY |
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| ZHANG Ding-lian,GUO Shao-chun,ZHENG Jia-geng,YUAN Jian-jian,WANG Bin.SYNTHESIS AND COMPARISON OF DIFFERENT ~(125)I-ESTRADIOL ANALOGE FOR ESTROGEN RADIO RECEPTOR ASSAY[J].Acta Agriculturae Nucleatae Sinica,2006,20(3):252-254. |
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| Authors: | ZHANG Ding-lian GUO Shao-chun ZHENG Jia-geng YUAN Jian-jian WANG Bin |
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| Institution: | 1. Institute for the Application of Atomic Energy, Chinese Academy of Agricultursl Sciences / Institute of Agro-Food Science and Technology, Chinese Acaderrsy of Agricultural Sciences/Key Laboratory of Agricultural Nuclear Technology and Agro-food Product Processing,Ministry of Agriculture,Beijing 100086;2.Beijing North Institute of Biotechnology,Beijing 100086 |
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| Abstract: | Radio Receptor Assay(RRA) for the Estrogen Receptor(ER) is important in cancer diagnostic and drug designation.7 kinds of()~(125)I-Estradiol analogs:()~(125)I-Estradiol-6-CMO-His,()~(125)I-Estradiol-3-CME-His,()~(125)I-Estradiol-17-HS-His,2-()~(125)I-Estradiol,4-IEstradiol,2,4-2()~(125)I-Estradiol,16α()~(125)I-Estradiol were synthesized and compared for Estrogen Radio Receptor Assay.It was found that 16α()~(125)I-Estradiol was better than()~3H-Estradiol and other()~(125)I-Estradiol analogs mentioned above for the RRA of Estrogen Receptor. |
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| Keywords: | Estrogen Receptor RRA ~(125)I-Estradiol radioligands |
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