| 昆虫蜕皮激素类似物的定量构效关系及其受体三维结构研究进展 |
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| 引用本文： | 阴斌,张莉,崔紫宁,凌云,杨新玲.昆虫蜕皮激素类似物的定量构效关系及其受体三维结构研究进展[J].农药学学报,2010,12(4):383-390. |
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| 作者姓名： | 阴斌 张莉 崔紫宁 凌云 杨新玲 |
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| 作者单位： | 1.中国农业大学 理学院 应用化学系/农业部农药化学与应用重点开放实验室,北京 100193 |
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| 基金项目： | 国家自然科学基金(20802089);农药与化学生物学教育部重点实验室开放基金(200803A02);元素有机化学国家重点实验室开放基金(0805);国家重点基础研究发展计划(973计划)项目(2010CB126104)资助. |
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| 摘 要： | 蜕皮激素及其类似物具有调节昆虫蜕皮、变态和繁殖的功能。蜕皮激素类似物在农业生产,尤其是鳞翅目害虫的防治中发挥着重要作用。总结近期的文献,同时结合课题组的工作,综述了蜕皮激素类似物的定量构效关系、蜕皮激素受体三维结构的研究进展。
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| 关 键 词： | 蜕皮激素 双酰肼 定量构效关系 蜕皮激素受体 |
| 收稿时间： | 2010/6/21 0:00:00 |
| 修稿时间： | 2010/9/25 0:00:00 |
Progress on quantitative structure-activity relationship of ecdysone analogues and the three-dimensional structure of ecdysone receptor |
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| YIN Bin,ZHANG Li,CUI Zi-ning,LING Yun and YANG Xin-ling.Progress on quantitative structure-activity relationship of ecdysone analogues and the three-dimensional structure of ecdysone receptor[J].Chinese Journal of Pesticide Science,2010,12(4):383-390. |
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| Authors: | YIN Bin ZHANG Li CUI Zi-ning LING Yun and YANG Xin-ling |
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| Institution: | 1.Key Laboratory of Pesticide Chemistry and Application,Ministry of Agriculture,Department of Applied Chemistry, College of Science,China Agricultural University,Beijing 100193,China |
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| Abstract: | Ecdysteroids and ecdysone analogues have the function of regulating insects’ molting,metamorphosis and reproduction.Ecdysone analogues play important roles in agricultural production,especially in the management of Lepidoptera pests.Based on the recent researches,the progress in quantitative structure-activity relationship of ecdysone anaogues and the three-dimensional structure of ecdysone receptor is reviewed. |
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| Keywords: | ecdysone diacylhydrazine quantitative structure-activity relationship(QSAR) ecdysone receptor(EcR) |
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