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| 中国荷斯坦牛凝血因子XI缺陷症遗传分析 | |
| 引用本文： | 东天,谢岩,孙东晓,张沅,张胜利,张毅,刘林,陈绍祜.中国荷斯坦牛凝血因子XI缺陷症遗传分析[J].中国奶牛,2011(22):27-29. |
| 作者姓名： | 东天 谢岩 孙东晓 张沅 张胜利 张毅 刘林 陈绍祜 |
| 作者单位： | 1. 中国农业大学动物科技学院,农业部畜禽遗传育种重点实验室,北京100193 2. 北京奶牛中心,北京,100085 3. 中国奶牛数据中心,北京,100085 |
| 基金项目： | 基金项目:受国家自然科学基金，转基因生物新品种培育重大专项，948项目 |
| 摘 要： | 凝血因子XI缺陷症（FactorXIdenciency）是荷斯坦牛的一种常染色体单基因控制的隐性遗传缺陷。该病的遗传基础是由位于牛第27号染色体的凝血因子XI基因外显子12上发生的一段76bp序列插入。本研究采用PCR方法对我国13个主要公牛站的571头荷斯坦公牛的凝血因子XI基因进行了全面检测，未发现隐性有害基因携带者和纯合个体。 |
| 关 键 词： | 中国荷斯坦公牛 凝血因子XI缺陷症 分子诊断 |
Identification of Factor XI Deficiency in Dairy Cattle |
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| DONG Tian,XIE Yan,SUN Dong-xiao,ZHANG Yuan,ZHANG Sheng-li,ZHANG Yi,LIU Lin,CHEN Shao-hu.Identification of Factor XI Deficiency in Dairy Cattle[J].China Dairy Cattle,2011(22):27-29. | |
| Authors: | DONG Tian XIE Yan SUN Dong-xiao ZHANG Yuan ZHANG Sheng-li ZHANG Yi LIU Lin CHEN Shao-hu |
| Institution: | DONG Tian1,XIE Yan1,SUN Dong-xiao1,ZHANG Yuan1,ZHANG Sheng-li1,ZHANG Yi1,LIU Lin2,CHEN Shao-hu3(1.College of Animal Science and Technology,China Agricultural University,Key Laboratory of Animal Genetics and Breeding,Ministry of Agriculture,Beijing 100193,2.Beijing Dairy Cattle Centrer,Beijing 100192,3.Data Center of China Dairy Cattle,Beijing 100192) |
| Abstract: | Factor XI deficiency is an autosomal recessive inherited defect in Holstein cattle. Affected animals showed a number of symptoms adversely affecting the reproductive performances of the cows and appeared more susceptible to diseases. The mechanism on this deficiency is the mutation for a 76 base insertion into exon 12 of FXI gene that causes Factor XI deficiency. In this study, based on the PCR method, 571 bulls from 13 bull stations were detected for the genotypes of Factor XI deficiency. No carrier bulls of Factor XI deficiency were found. |
| Keywords: | Chinese Holstein bull Factor XI deficiency Molecular diagnosis |
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