| 滋肾活血方对血管性痴呆大鼠NR2A表达的影响 |
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| 引用本文： | 任晨斌,伍大华,郭晨,谢乐. 滋肾活血方对血管性痴呆大鼠NR2A表达的影响[J]. 勤云标准版测试, 2018, 38(2): 141-144 |
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| 作者姓名： | 任晨斌 伍大华 郭晨 谢乐 |
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| 作者单位： | 湖南省中医药研究院附属医院, 湖南 长沙 410006,湖南省中医药研究院附属医院, 湖南 长沙 410006,宁波老年康复医院, 浙江 宁波 315033,湖南省中医药研究院附属医院, 湖南 长沙 410006 |
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| 基金项目： | 湖南省中医药管理局重点项目（201528）。 |
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| 摘 要： | 目的 探讨滋肾活血方对血管性痴呆（vascular dementia，VD）大鼠NR2A表达的影响。方法 采用改良的双侧颈总动脉结扎法（2-VO法）制作VD大鼠模型，将其随机分为假手术组、模型组、滋肾活血组及奥拉西坦组。给药4周后，用免疫组化和RT-PCR检测NR2A及其mRNA的表达。结果 与假手术组相比，模型组NR2A及其mRNA表达均降低（P<0.05）；与模型组相比，滋肾活血组及奥拉西坦组NR2A及其mRNA表达增高（P<0.05）。结论 滋肾活血方可提高VD大鼠的学习记忆能力，这可能与上调NR2A的表达有关。
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| 关 键 词： | 滋肾活血方 血管性痴呆 N-甲基-D-天门冬氨酸 |
| 收稿时间： | 2017-02-19 |
Effect of Zishen Huoxue Decoction on Expression of NR2A in Rats with Vascular Dementia |
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| REN Chenbin,WU Dahu,GUO Chen and XIE Le. Effect of Zishen Huoxue Decoction on Expression of NR2A in Rats with Vascular Dementia[J]. , 2018, 38(2): 141-144 |
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| Authors: | REN Chenbin WU Dahu GUO Chen XIE Le |
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| Affiliation: | The Affiliated Hostipal of Hunan Institute of Traditional Chinese Medicine, Changsha, Hunan 410006, China,The Affiliated Hostipal of Hunan Institute of Traditional Chinese Medicine, Changsha, Hunan 410006, China,Ningbo Geriatric Rehabilitation Hospital, Ningbo, Zhejiang 315033, China and The Affiliated Hostipal of Hunan Institute of Traditional Chinese Medicine, Changsha, Hunan 410006, China |
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| Abstract: | Objective To investigate the effect of Zishen Huoxue decoction on the expressiom of NR2A in rats with vascular dementia (VD).Methods This VD model rats were built by the improved 2-VO. The rats were randomly divide into the sham-operation group, the model group, the Zishen Huoxue group and the oxiracetam group. After giving medicine for 4 weeks later, the expression of NR2A and its mRNA were measured by immunohistochemical analysis and RT-PCR.Results Compared with the model group, the expression of NR2A and its mRNA in Zishen Huoxu decoction group and oxiracetam group increased (P<0.05).Conclusion Zishen Huoxue decoction could improve the ability of learning and memory, which might be associated with the up-regulation of the expression of NR2A. |
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| Keywords: | Zishen Huoxue decoction vascular dementia N-methyl-D-aspartate |
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