Activity changes of glyoxalase system enzymes and glutathione-S-transferase in the bivalve mollusc Scapharca inaequivalvis exposed to the organophosphate chlorpyrifos |
| |
Authors: | Cinzia Antognelli Baldracchini Francesca Piazzoli Andrea Frosini Roberta Talesa Vincenzo Giovannini Elvio |
| |
Institution: | Department of Experimental Medicine, Division of Cellular and Molecular Biology, University of Perugia, Via del Giochetto, O6122 Perugia, Italy |
| |
Abstract: | The present report was aimed to study possible changes in the activity of glutathione-dependent enzymes glyoxalase I (G I) and glyoxalase II (G II), forming the glyoxalase system, and glutathione-S-transferase in tissues (gills, foot, and digestive gland) of the mediterranean bivalve mollusc Scapharca inaequivalvis, after a 4- or 15-day exposure to a sublethal concentration (0.1 ppm) of the organophosphate pesticide chlorpyrifos (CPF). Control experiments were also performed on untreated animals. G I activity decreased in gills and foot, and increased in the digestive gland after 4 days of CPF exposure. Glyoxalase II activity in the gills decreased after a 15 days exposure to CPF, was unchanged in the foot and increased after 15 days in the digestive gland. Glutathione-S-transferase activity, which is involved in the detoxification of xenobiotics, increased significantly in all tissues after CPF exposure. The results suggest that sublethal CPF exposure of S. inaequivalvis does not compromise the cellular redox balance in these tissues. |
| |
Keywords: | Glyoxalase I Glyoxalase II Glutathione-S-transferase Chlorpyrifos toxicity Bivalve Clam Scapharca inaequivalvis |
本文献已被 ScienceDirect 等数据库收录! |
|