Simian virus 40: replication in the presence of specific antiserum and adenovirus 4

Twelve consecuttive passages of simian virus 40, made in the presence of adenovirus 4 and antiserum to simian virus 40, indicated that simian virus 40 would multiply almost indefinitely under these conditions. The adenovirus and the simian virus had previously replicated together in the absence of antiserum. These data support the conclusion that the SV-40 genome is incorporated within the protein coats of adenovirus 4.