| DNA干扰研究进展 |
| |
| 引用本文： | 陈启伟,王永录.DNA干扰研究进展[J].动物医学进展,2009,30(1). |
| |
| 作者姓名： | 陈启伟 王永录 |
| |
| 作者单位： | 中国农业科学院兰州兽医研究所家畜疫病病原生物学国家重点实验室农业部畜禽病毒学重点开放实验室,甘肃,兰州,730046 |
| |
| 摘 要： | DNA干扰(DNAi)即含有与体内某一基因的cDNA相同序列的DNA链,在没有启动子诱发其表达的情况下导致细胞内序列特异的基因表达被抑制.DNA干扰可参与真核生物的抗病毒侵粢,阻断转座子的异常活动,调控基因表达等.随着RNA干扰技术缺陷的暴露以及人们对多种同源基因依赖性基因沉默的深入了解,DNAi有望成为最有潜力的基因干预治疗方法,并将在抵抗人类重大疾病和基因治疗方面发挥重要作用.
|
| 关 键 词： | DNA干扰 基因沉默 基因阻滞 |
Advance in DNA Interference |
| |
| CHEN Qi-wei WANG Yong-lu.Advance in DNA Interference[J].Progress In Veterinary Medicine,2009,30(1). |
| |
| Authors: | CHEN Qi-wei WANG Yong-lu |
| |
| Institution: | Key Laboratory of Animal Virology of Agriculture/State Key Laboratory of Veterinary Etiological Biology;Lanzhou VeterinaryResearch Institute;Chinese Academy of Agricultural Sciences;Lanzhou;Gansu;730046;China |
| |
| Abstract: | DNA interference(DNAi),which contains a gene in the body of the cDNA sequences of the same DNA chain,in the absence of its promoter-induced expression of the cells leads to the sequence-specific inhibition of gene expression.DNAi participates in antiviral infections in eukaryon,blocks the abnormal activity of transposon,and regulates the expression of protein-coding genes,and so on.With the defective RNA interference technology,as well as the understanding to a wide range of genetic homology-dependent gene ... |
| |
| Keywords: | DNAi gene silencing gene block |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
