Isolation and Identification of Antitrypanosomal and Antimycobacterial Active Steroids from the Sponge Haliclona simulans |
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| Authors: | Christina Viegelmann Jennifer Parker Thengtheng Ooi Carol Clements Gráinne Abbott Louise Young Jonathan Kennedy Alan D W Dobson RuAngelie Edrada-Ebel |
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| Institution: | 1.Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, The John Arbuthnott Building, 161 Cathedral Street, Glasgow, Scotland G4 0RE, UK; E-Mails: (J.P.); (T.O.); (C.C.); (G.A.); (L.Y.);2.Marine Biotechnology Centre, Environmental Research Institute, University College Cork, Lee Road, Cork, Ireland; E-Mails: (J.K.); (A.D.W.D.) |
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| Abstract: | The marine sponge Haliclona simulans collected from the Irish Sea yielded two new steroids: 24-vinyl-cholest-9-ene-3β,24-diol and 20-methyl-pregn-6-en-3β-ol,5α,8α-epidioxy, along with the widely distributed 24-methylenecholesterol. One of the steroids possesses an unusually short hydrocarbon side chain. The structures were elucidated using nuclear magnetic resonance spectroscopy and confirmed using electron impact- and high resolution electrospray-mass spectrometry. All three steroids possess antitrypanosomal and anti-mycobacterial activity. All the steroids were found to possess low cytotoxicity against Hs27 which was above their detected antitrypanosomal potent concentrations. |
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| Keywords: | Haliclona simulans marine sponges steroids antitrypanosomal anti-mycobacterial |
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