Three New Resveratrol Derivatives from the Mangrove Endophytic Fungus Alternaria sp. |
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| Authors: | Jinhua Wang Daniel G Cox Weijia Ding Guanghao Huang Yongcheng Lin Chunyuan Li |
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| Institution: | 1.Institute of Biomaterial, College of Science, South China Agricultural University, Guangzhou 510642, China; E-Mails: (J.W.); (W.D.); (G.H.); (C.L.);2.Department of Pharmacognosy and Research Institute of Pharmaceutical Sciences, School of Pharmacy, Mississippi University, Oxford, MS 38677, USA; E-Mail: ;3.School of Chemistry and Chemical Engineering, Sun Yat-sen University, 135 Xingang West Road, Guangzhou 510275, China; E-Mail: |
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| Abstract: | Three new resveratrol derivatives, namely, resveratrodehydes A–C (1–3), were isolated from the mangrove endophytic fungus Alternaria sp. R6. The structures of these compounds were elucidated by analysis of their MS, 1D and 2D NMR spectroscopic data. All compounds showed broad-spectrum inhibitory activities against three human cancer cell lines including human breast MDA-MB-435, human liver HepG2, and human colon HCT-116 by MTT assay (IC50 < 50 μM). Among them, compounds 1 and 2 both exhibited marked cytotoxic activities against MDA-MB-435 and HCT-116 cell lines (IC50 < 10 μM). Additionally, compounds 1 and 3 showed moderate antioxidant activity by DPPH radical scavenging assay. |
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| Keywords: | marine fungus Alternaria sp mangrove stilbenes resveratrol antioxidant antitumor |
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