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Development of Marine-Derived Compounds for Cancer Therapy
Authors:Weimin Zuo  Hang Fai Kwok
Institution:1.Cancer Centre, Faculty of Health Sciences, University of Macau, Avenida de Universidade, Taipa, Macao;2.MoE Frontiers Science Center for Precision Oncology, University of Macau, Taipa, Macao
Abstract:Cancer has always been a threat to human health with its high morbidity and mortality rates. Traditional therapy, including surgery, chemotherapy and radiotherapy, plays a key role in cancer treatment. However, it is not able to prevent tumor recurrence, drug resistance and treatment side effects, which makes it a very attractive challenge to search for new effective and specific anticancer drugs. Nature is a valuable source of multiple pharmaceuticals, and most of the anticancer drugs are natural products or derived from them. Marine-derived compounds, such as nucleotides, proteins, peptides and amides, have also shed light on cancer therapy, and they are receiving a fast-growing interest due to their bioactive properties. Their mechanisms contain anti-angiogenic, anti-proliferative and anti-metastasis activities; cell cycle arrest; and induction of apoptosis. This review provides an overview on the development of marine-derived compounds with anticancer properties, both their applications and mechanisms, and discovered technologies.
Keywords:marine-derived compounds  cancer therapy  mechanism  technology
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