The effects of 10% hypertonic saline, 0.9% saline and hydroxy ethyl starch infusions on hydro-electrolyte status and adrenal function in healthy conscious dogs |
| |
| Affiliation: | 1. SIAMU, École Nationale Vétérinaire de Lyon, 1 avenue Bourgelat, B.P. 83, 69280 Marcy l’Étoile, France;2. Université de Lyon, INSERM ERI 22, France;3. Biochemistry Unit, École Nationale Vétérinaire de Lyon, 1 avenue Bourgelat, B.P. 83, 69280 Marcy l’Étoile, France;4. Physiology Unit, École Nationale Vétérinaire de Lyon, 1 avenue Bourgelat, B.P. 83, 69280 Marcy l’Étoile, France;1. Graduate Program in Veterinary Medicine, Department of Small Animal, Veterinary Hospital, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil;2. Department of Animal Science, Universidade do Estado de Santa Catarina, Chapecó, SC, Brazil;3. Graduate Program in Veterinary Medicine, Department of Microbiology and Parasitology, Prédio 20, Universidade Federal de Santa Maria, Santa Maria , RS, Brazil;4. Graduate Program in Biological Sciences: Toxicological Biochemistry, Division of Biochemistry and Oxidative Stress, Laboratory of Cell Therapy, Centro de Ciências Rurais, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil;5. Graduate Program in Biological Sciences: Toxicological Biochemistry, Laboratory of Toxicology Enzymology, Department of Chemistry, Centro de Ciências Naturais e Exatas; Universidade Federal de Santa Maria, Santa Maria, RS, Brazil;6. Instituto de Pesquisas Veterinárias Desidério Finamor, Fundação Estadual de Pesquisa Agropecuária (FEPAGRO), Eldorado do Sul, RS , Brazil;7. Centre for Biological Sciences, Department of Epidemiology and Microbiology, Health Sciences, Universidade Federal do Piauí, Campus Senador Helvídio Nunes de Barros,Picos, PI , 64600-000, Brazil;1. University of Bonn, Institute for Animal Science, Katzenburgweg 7-9, 53115 Bonn, Germany;2. Chamber of Agriculture North Rhine-Westphalia, Center of Agriculture Haus Riswick, Elsenpaß 5, 47533, Kleve, Germany;3. Christian-Albrechts-University, Institute of Animal Breeding and Husbandry, Olshausenstr 40, 24098 Kiel, Germany;4. Educational and Research Centre for Animal Husbandry, Hofgut Neumuehle, 67728 Münchweiler an der Alsenz, Germany;5. Landwirtschaftliches Zentrum Baden-Württemberg (LAZBW), Atzenberger Weg 99, 88326 Aulendorf, Germany;6. Bavarian State Research Center for Agriculture, Institute for Animal Nutrition and Feed Management, Prof-Dürrwaechter-Platz 3, 85586 Poing, Germany;7. Center for Agricultural Learning, Markgrafenstraße 1, 91746 Weidenbach, Germany;8. Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Bundesallee 37, 38116 Braunschweig, Germany;9. Institute for the Biology of Farm Animals (FBN), Institute of Nutritional Physiology “Oskar Kellner”, Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany;10. TiDa Tier und Daten GmbH, Bosseer Street 4c, 24259 Westensee, Brux, Germany;1. Department of Internal Medicine, Faculty of Veterinary Medicine, Uludag University, Bursa 16059, Turkey;2. Medical-Surgical Research Center, Agricultural Faculty, Osmangazi University Eskişehir, Turkey;3. Departament de Medicina i Cirurgia Animals, Universitat Autònoma de Barcelona, 08193, Bellaterra, Barcelona, Spain;4. Department of Pharmacology, Medical Faculty, Uludag University, Bursa, Turkey;5. Department of Veterinary Pathology, Faculty of Veterinary Medicine, Uludag University, Bursa, Turkey;6. Interdisciplinary Laboratory of Clinical Analysis (Interlab-UMU), Veterinary School, Campus of Excellence Mare Nostrum, University of Murcia, 30100 Espinardo, Murcia, Spain;1. DST/NRF Centre of Excellence for Biomedical TB Research/MRC Centre for Tuberculosis Research/Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, PO Box 19063, Tygerberg 7505, South Africa;2. Ezemvelo KZN Wildlife, PO Box 25, Mtubatuba 3935, South Africa;1. Department of Animal Sciences and Industry, Kansas State University, Manhattan, KS, 66506, USA;2. Department of Chemistry, Kansas State University, Manhattan, KS, 66506, USA;3. Department of Anatomy and Physiology, Kansas State University, Manhattan, KS, 66506, USA;4. Department of Large Animal Clinical Sciences, University of Florida, Gainesville, FL, 32610, USA;5. Department of Animal Sciences, University of Florida, Gainesville, FL, 32611, USA |
| |
| Abstract: | The purpose of this study was to investigate the influence of different saline and colloid solutions on adrenal steroid secretion in dogs. Six healthy male Beagles underwent three infusion cycles: 10 min infusion of 30 ml/kg of NaCl 0.9%, 5 ml/kg of hydroxy ethyl starch, or 5 ml/kg of NaCl 10%. Plasma osmolality, hematocrit, total solids, cortisol and aldosterone levels were measured at 0, 5, 15, 30, 60, 120, 180 and 240 min after beginning infusion. Plasma ACTH levels were measured at 0, 15 and 240 min. An identical timing of sampling was applied during a control session omitting the fluid infusion. Osmolality, sodium, chloride and cortisol levels were found to be significantly higher with hypertonic saline solute compared to control. All fluid infusions lead to lowered plasma potassium, hematocrit, total solids and aldosterone values. ACTH concentrations did not show significant changes with any of the infusion cycles. The increase in cortisol levels suggests that hypertonic saline infusion could be interesting in critical care resuscitation, particularly in patients who are suffering from relative adrenal insufficiency. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
