Four New Chromones from the Endophytic Fungus Phomopsis asparagi DHS-48 Isolated from the Chinese Mangrove Plant Rhizophora mangle |
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| Authors: | Chengwen Wei Chunxiao Sun Zhao Feng Xuexia Zhang Jing Xu |
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| Institution: | 1.School of Chemical Engineering and Technology, Hainan University, Haikou 570228, China; (C.W.); (Z.F.); (X.Z.);2.School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China; |
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| Abstract: | Four new chromones, phomochromenones D–G (1–4), along with four known analogues, diaporchromone A (5), diaporchromanone C (6), diaporchromanone D (7), and phomochromenone C (8), were isolated from the culture of Phomopsis asparagi DHS-48 from Chinese mangrove Rhizophora mangle. Their structures were elucidated on the basis of comprehensive spectroscopic analysis. The absolute configurations of 1 and 4 were assigned on the basis of experimental and calculated electronic circular dichroism (ECD) data, and those of enantiomers 2 and 3 were determined by a modified Mosher’s method and basic hydrolysis. To the best of our knowledge, phomochromenones D–F (1–4) possessing a 3-substituted-chroman-4-one skeleton are rarely found in natural sources. Diaporchromone A (5) showed moderate to weak immunosuppressive activity against T and/or B lymphocyte cells with IC50 of 34 μM and 117 μM. |
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| Keywords: | mangrove endophytic fungi Phomopsis sp chromenones immunosuppressive activity |
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