Six New Diterpene Glycosides from the Soft Coral Lemnalia
bournei |
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| Authors: | Xia Yan Han Ouyang Te Li Yutong Shi Bin Wu Xiaojun Yan Shan He |
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| Affiliation: | 1.Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315800, China; (X.Y.); (T.L.); (Y.S.); (X.Y.);2.Institute of Drug Discovery Technology, Ningbo University, Ningbo 315211, China;3.Ocean College, Zhejiang University, Hangzhou 310058, China; |
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| Abstract: | A chemical study on the extracts of soft coral Lemnalia bournei resulted in the isolation and identification of six new bicyclic diterpene glycosides including three new lemnaboursides E–G (1–3), and three new lemnadiolboursides A–C (4–6), along with three known lemnaboursides (7–9). Their structures were elucidated by detailed spectroscopic analysis, ECD analysis, chemical methods, and comparison with the literature data. Lemnadiolboursides A–C (4–6) contained a lemnal-1(10)-ene-7,12-diol moiety compared with the lemnaboursides. All these compounds were evaluated for antibacterial activity; cell growth inhibition of A549, Hela, HepG2, and CCRF-CEM cancer cell lines; and inhibition of LPS-induced NO production in RAW264.7 macrophages. The results indicated that compounds 1, 2, and 4–6 exhibited antibacterial activity against Staphylococcus aureus and Bacillus subtilis (MIC 4–16 μg/mL); compounds 1–9 displayed low cytotoxicity on the CCRF-CEM cell lines (IC50 10.44–27.40 µM); and compounds 1, 2, and 5 showed weak inhibition against LPS-induced NO production (IC50 21.56–28.06 μM). |
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| Keywords: | soft coral diterpene glycosides Lemnalia bournei antimicrobial activity |
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