GC-MS quantitation of fragrance compounds suspected to cause skin reactions. 1 |
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Authors: | Chaintreau Alain Joulain Daniel Marin Christophe Schmidt Claus-Oliver Vey Matthias |
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Institution: | Analytical Working Group of the International Fragrance Association (IFRA), Square Marie-Louise 49, B-1000 Brussels, Belgium. alain.chaintreau@firmenich.com |
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Abstract: | Recent changes in European legislation require monitoring of 24 volatile compounds in perfumes as they might elicit skin sensitization. This paper reports a GC-MS quantitation procedure for their determination in fragrance concentrates. GC and MS conditions were optimized for a routine use: analysis within 30 min, solvent and internal standard selection, and stock solution stability. Calibration curves were linear in the range of 2-100 mg/L with coefficients of determination in excess of 0.99. The method was tested using real perfumes spiked with known amounts of reference compounds. |
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