| 三维基因组学概述及其在农业生物育种方面的研究进展 |
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| 引用本文： | 任妍妍,彭巍,刘贤,赵杨杨,张子敬,付长其,张君,田全召,王二耀,雷初朝,黄永震. 三维基因组学概述及其在农业生物育种方面的研究进展[J]. 中国牛业科学, 2022, 48(6): 70-75 |
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| 作者姓名： | 任妍妍 彭巍 刘贤 赵杨杨 张子敬 付长其 张君 田全召 王二耀 雷初朝 黄永震 |
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| 作者单位： | 西北农林科技大学动物科技学院,,,,,,,,,西北农林科技大学动物科技学院,西北农林科技大学动物科技学院 |
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| 基金项目： | 国家现代农业产业技术体系资助（CARS-37）；青海省重大科技专项（2021-NK-A5）；青海省科技计划（2021-ZJ-736）；河南省科技攻关（222102110069）；河南省农业科学院自主创新专项基金（2022C45）；西北农林科技大学2021年大学生创新创业训练计划项目资助完成（202110712041，X202110712179，S202110712269） |
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| 摘 要： | 真核细胞中染色质以不同层次的三维结构有序的折叠在细胞核中,其空间层次结构对基因的表达调控和细胞发挥正常的生理功能都起着重要的作用,在动物育种方面具有很大潜力,但尚未被完全探索。本文介绍三维基因组的结构单元(染色质疆域、A/B 区室、拓扑关联结构域和染色质环)以及研究三维基因组的主要技术,对三维基因组学在农业中的研究进展和应用前景进行了探讨,旨在深入了解三维基因组学的功能和应用前景,以期为生物育种改良提供部分帮助。
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| 关 键 词： | 三维基因组 三维基因组研究技术 农业生物育种 |
| 收稿时间： | 2022-06-24 |
| 修稿时间： | 2022-09-26 |
An overview of three-dimensional genomics and its research advances in agricultural biological breeding |
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| Ren Yanyan,Peng Wei,Liu Xian,Zhao Yangang,Zhang Zi-jing,Fu Changqi,Zhang Jun,Tian Quanzhao,Wang Er-yao,Lei Chuzhao and Huang Yongzhen. An overview of three-dimensional genomics and its research advances in agricultural biological breeding[J]. China Cattle Science, 2022, 48(6): 70-75 |
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| Authors: | Ren Yanyan Peng Wei Liu Xian Zhao Yangang Zhang Zi-jing Fu Changqi Zhang Jun Tian Quanzhao Wang Er-yao Lei Chuzhao Huang Yongzhen |
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| Affiliation: | College of Animal Science and Technology,Northwest Agriculture and Forestry University,Yangling,Shaanxi,,,,,,,,,,College of Animal Science and Technology,Northwest Agriculture and Forestry University,Yangling,Shaanxi |
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| Abstract: | The chromosome in eukaryotic cells folds in the nucleus in an orderly manner with different levels of three-dimensional structure, and its spatial hierarchy plays an important role in the regulation of gene expression and the normal physiological function of cells, which has great potential in animal breeding, but has not yet been fully explored. This paper introduces the structural units of the three-dimensional genome (chromatin domain, A/B zone, topological association domain and chromatin ring) and the main technologies for studying the three-dimensional genome, discusses the research progress and application prospects of three-dimensional genomics in agriculture, and aims to gain an in-depth understanding of the functions and application prospects of three-dimensional genomics, with a view to providing partial help for biological breeding and improvement. |
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| Keywords: | 3D genomics 3D genomics research techniques biological breeding |
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