实验诱发长爪沙鼠中风模型的研究──方法的建立及中风发病情况与性别的关系

手术截断长爪沙鼠一侧颈动脉以引发沙鼠中风，总有效率为５４．４２％。手术后４～６ｈ，发现雄、雌沙鼠的总发病率分别为６４．０１％和４４．４４％。其中轻度中风率分别为３０．６７％和１９．４４％；中度中风率分别为１４．６７％和１５．２８％；严重中风率分别为１８．６７％和９．７２％。雄性发病率及中风程度明显比雌性严重（Ｐ＜０．０５）。建议采用雄性沙鼠作为中风模型的材料，有利于提高模型的成功率。经进一步观察，又发现术后４～６ｈ时所表现的体症可作为判断模型成功与否的依据。

A STUDY ON EXPERIMENTALLY INDUCED STROKE IN MONGOLIAN GERBILS

? hours after ligation of a single common carotid artery in Mongolian gerbils, the rate of stroke is 54. 42% in gerbils(64.01% in male and 44.44% in female respectively).The rate of mildly symptomatic are 30.67% and 19.44%,the rate of moderately symptomatic are 14. 67% and 15.28% and the rate of severely symptomatic are 18.67% and are 9.72% in male and in female respectively.The stroke of the male is more severely than that of the female(t=2.0409,P<0. 05) o it was found that the male is better than the female in making the stroke model. The symptom at 4-6 hours after ligation can be used to distinguish whether the stroke appears in gerbils.