| 成纤维细胞生长因子23与慢性肾病的研究 |
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| 引用本文： | 孙常文,刘孝菊,陈玉斌,李校堃. 成纤维细胞生长因子23与慢性肾病的研究[J]. 现代农业科技, 2011, 0(1): 11-12,14 |
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| 作者姓名： | 孙常文 刘孝菊 陈玉斌 李校堃 |
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| 作者单位： | 孙常文,SUN Chang-wen(吉林农业大学生物反应器与药物开发教育部工程研究中心,吉林长春,130118;吉林农业大学生命科学学院);刘孝菊,李校堃,LIU Xiao-ju,LI Xiao-kun(吉林农业大学生物反应器与药物开发教育部工程研究中心,吉林长春,130118;吉林大学公共卫生学院;温州医学院药学院);陈玉斌,CHEN Yu-bin(吉林农业大学生物反应器与药物开发教育部工程研究中心,吉林长春,130118) |
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| 摘 要： | 成纤维细胞生长因子23与人类许多疾病相关,它不仅可以直接调节钙、磷代谢,而且可以间接调节甲状旁腺激素、维生素D代谢。FGF23和klotho蛋白对维持磷酸盐的浓度、血管和骨骼都具有其独特的意义。主要通过与磷酸盐对比,提出了FGF23可以独立预测慢性肾病的不利结果,最后指出FGF23抗体和其C-末端在慢性肾脏疾病的治疗上具有潜力。
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| 关 键 词： | FGF23 慢性肾病 磷酸盐 研究 |
Research on Fibroblast Growth Factor-23 and Chronic Kidney Disease |
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| SUN Chang-wen,LIU Xiao-ju,CHEN Yu-bin,LI Xiao-kun. Research on Fibroblast Growth Factor-23 and Chronic Kidney Disease[J]. Modern Agricultural Sciences and Technology, 2011, 0(1): 11-12,14 |
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| Authors: | SUN Chang-wen LIU Xiao-ju CHEN Yu-bin LI Xiao-kun |
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| Affiliation: | SUN Chang-wen 1,2 LIU Xiao-ju 1,3,4 CHEN Yu-bin 1 LI Xiao-kun 1,4(1 Engineering Research Center of Bioreactor and Pharmaceutical Development,Ministry of Education,Jilin Agricultural University,Changchun Jilin 130118,2 School of Life Science,3 School of Public Health of Jilin University,4 Key Laboratory of Biotechnology Pharmaceutical Engineering,Wenzhou Medical College) |
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| Abstract: | Many human diseases are associated with FGF23,it can directly regulate calcium and phosphorus metabolism and can indirectly regulate parathyroid hormone,vitamin D metabolism.FGF23 and klotho is related to the leve of phosphate,blood vessels and bone.Compare with phosphates,it showed that FGF23 can predict the adverse outcomes of chronic kidney disease,finally it was pointed out that the antibody of FGF23 and C-terminal had potential in the treament of chronic kidney disease. |
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| Keywords: | FGF23 |
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