猫免疫缺陷病毒在医学中的应用

猫免疫缺陷病毒(Feline immunodeficiency virus,FIV)是一种主要感染猫的反转录病毒.FIV与人的免疫缺陷病毒(Human immunodeficiency virus,HIV)有许多相似性,可作为HIV的研究模型,如测量FIV病毒在动物体内的感染曲线,可为了解HIV在人体内的传播细节提供蓝图;利用FIV偏好感染发展中的神经系,可以帮助人们了解艾滋病(Acquired immure deficiency syndrome,AIDS)对神经系统的致病机理.FIV疫苗的研究获得成功,可为HIV疫苗的研制提供提示.FIV在基因治疗方面有重要的应用价值,目前应用FIV传递CFTR(cystic fibrosis transmembrane conductance regulator)的cDNA到呼吸系统表皮细胞治疗囊肿性纤维化(cystic fibrosis,CF)的研究已经取得了很大进展.

The Application of Feline immunodeficiency virus in Medicine

Feline immunodeficiency virus(FIV)is a kind of retrovirus that mainly infect feline.Since it shares much similarity with HIV in capsite structure,gene strcture,gene variation,it was used as a research model of HIV in the investigation of detailed dynamoics of HIV in human and in gene cure.The success of FIV vaccine could be a clue on the research of HIV vaccine.FIV was practically valueable in gene cure as well.Using FIV,great progress has made on the delivering cDNA of CFTR(cystic fibrosis transmembrane conductance regulator)to epithetlial cells of respiratory system to treat cystic fibrosis.