Central L-cysteine induces sleep, and D-cysteine induces sleep and abnormal behavior during acute stress in neonatal chicks |
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| Authors: | Haruka YAMANE Mari ASECHI Yousuke TSUNEYOSHI D. Michael DENBOW Mitsuhiro FURUSE |
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| Affiliation: | Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresources and Bioenvironmental Sciences, Kyushu University, Higashi, Fukuoka, Japan;and;Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA |
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| Abstract: | L-Cysteine (L-Cys) is a non-essential and glycogenic amino acid. Previously, we reported that the intracerebroventricular (i.c.v.) injection of L-Cys induced sedative effects under isolation-induced stress in neonatal chicks. L-Cys has an optical isomer, D-Cys. The aim of this study was to clarify the effect of L-Cys and D-Cys during a stressful condition in chicks. The i.c.v. injection of L-Cys and D-Cys (0.84 µmol) decreased both distress vocalization and spontaneous activity induced by isolation. However, the two cysteine isomers induced different behaviors. L-Cys increased sleep-like behavior while D-Cys caused abnormal behavior including syncope as well as sleep-like behavior. In conclusion, while both L-Cys and D-Cys caused a sedative effect when injected i.c.v, D-Cys caused abnormal behavior and may be detrimental to neonatal chicks. |
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| Keywords: | D-cysteine intracerebroventricular injection L-cysteine neonatal chick social separation stress |
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