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Diagnostic accuracy of plasma atrial natriuretic peptide concentrations in cats with and without cardiomyopathies
Authors:Y Heishima  Y Hori  K Nakamura  Y Yamashita  N Isayama  N Kanno  M Katagi  H Onodera  S Yamano  Y Aramaki
Institution:1. School of Veterinary Medicine, Rakuno Gakuen University, 582 Midoricho, Bunkyodai, Ebetsu, Hokkaido 069-8501, Japan;2. Heisei Animal Hospital, 2-1-1 Futago-cho, Kasugai, Aichi 486-0955, Japan;3. Organization for Promotion of Tenure Track, University of Miyazaki, 1-1 Gakuenkibanadai-nishi, Miyazaki 889-2192, Japan;4. Ebisu Animal Hospital, 3-3-43 Nishitaga, Taihaku Ward, Sendai, Miyagi 982-0034, Japan;5. Uenonomori Animal Clinic, 1-5-11 Yanaka Taito Ward, Tokyo 110-0001, Japan;6. Department of Veterinary Medicine, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252-8510, Japan;7. Katagi Animal Hospital, 565-5 Matoba, Kawagoe, Saitama 350-1101, Japan;8. Onodera Animal Hospital, 1-10-4 Chuou, Rifu-cho, Miyagi 981-0104, Japan;9. Ueda Animal Clinic, 2-202 Ueda, Tenpaku Ward, Nagoya, Aichi 465-0051, Japan;10. Bay Veterinary Hospital, 5-6-7 Ujinanishi, Minami Ward, Hiroshima 734-0014, Japan
Abstract:

Objectives

Plasma atrial natriuretic peptide (ANP) levels have been reported to be elevated in cats with cardiomyopathy. We investigated the diagnostic accuracy of plasma ANP concentration as an indicator of the severity of cardiomyopathies.

Animals

This study included 78 control cats and 83 cats with various types of cardiomyopathy.

Methods

This was a prospective multicentre study. Control cats were determined to have a normal heart, and diseased cats were diagnosed by echocardiography. Diseased cats were divided into asymptomatic cats without left atrial dilation (LAD), asymptomatic cats with LAD, and cats with heart failure. Plasma C-terminal ANP concentrations were measured using chemiluminescence.

Results

The median plasma ANP concentration in controls was 43.3 (interquartile range, 33.0–56.3) pg/mL. Plasma ANP values were significantly higher in the cardiomyopathic cats with LAD and heart failure, but the values in cats without LAD were comparable to those in control cats. To distinguish cats with cardiomyopathy from controls, a plasma ANP concentration >77.5 pg/mL afforded sensitivity of 66.3% and specificity of 84.6%. Use of plasma ANP concentration >110.9 pg/mL to identify cats with LAD had a sensitivity of 73.6% and specificity of 93.5%. The areas under the receiver-operating characteristic curve were 0.80 and 0.86.

Conclusions

Plasma ANP concentrations were higher in cats with more advanced cardiomyopathy. Although assaying the ANP concentration alone may not help to diagnose cardiac disease, measuring provides additional information that is useful for assessing the severity of cardiomyopathies.
Keywords:Cardiac biomarker  Feline  Heart disease  Heart failure  Hypertrophic cardiomyopathy
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