| 哺乳动物味觉感受器T1Rs受体家族及信号转导机制的研究进展 |
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| 引用本文： | 单俐敏,张春雷,陈宏,房兴堂. 哺乳动物味觉感受器T1Rs受体家族及信号转导机制的研究进展[J]. 中国牛业科学, 2010, 36(4): 47-50 |
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| 作者姓名： | 单俐敏 张春雷 陈宏 房兴堂 |
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| 作者单位： | 徐州师范大学细胞与分子生物学研究所,江苏,徐州,221116;徐州师范大学细胞与分子生物学研究所,江苏,徐州,221116;西北农林科技大学动物科技学院,陕西省农业分子生物学重点实验室,陕西,杨凌,712100 |
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| 基金项目： | 江苏省高校自然科学基金,国家高技术研究发展计划项目,国家自然科学基金项目,转基因生物新品种培育科技重大专项项目,国家肉牛产业体系项目,陕西省13115科技创新工程项目 |
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| 摘 要： | 味觉受体第一家族（T1Rs）是一类能感知甜味和鲜味的受体家族,它包括T1R1,T1R2,T1R3三个成员。T1R2＋T1R3以异二聚体形式共表达参与甜味识别,而T1R1＋T1R3也以异二聚体形式共表达参与鲜味识别。良好的味觉能促进牛的食欲,促进生长发育,但目前关于牛的T1Rs受体家族的研究并不多见,有必要对这个受体家族做进一步探索。本文从甜味和鲜味两个方面对这一受体家族的分子结构及信号转导机制的最新研究进展做简要综述。
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| 关 键 词： | 味觉受体第一家族 信号转导 甜味识别 鲜味识别 |
The Research Progress of T1R Receptors and Signaling Transduction Mechanism in Mammals |
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| SHAN Li-min,ZHANG Chun-lei,CHEN Hong,FANG Xing-tang. The Research Progress of T1R Receptors and Signaling Transduction Mechanism in Mammals[J]. China Cattle Science, 2010, 36(4): 47-50 |
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| Authors: | SHAN Li-min ZHANG Chun-lei CHEN Hong FANG Xing-tang |
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| Affiliation: | 1.Institute of Cellular and Molecular Biology,School of Life Science,Xuzhou Normal University,Xuzhou,Jiangsu 221116,China;2.College of Animal Science and Technology,Northwest A＆F University,Shaanxi Key Laboratory of Agricultural Molecular Biology,Yangling,Shaanxi 712100,China) |
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| Abstract: | The T1Rs receptors,a family of taste-specific class CG protein coupled receptors for sweet taste and umami taste,include T1R1,T1R2 and T1R3.T1R2＋T1R3 heterodimers mediate mammalian sweet taste.T1R1＋T1R3 heterodimers mediate mammalian umami taste.Good taste could promote the cattle＇s appetite and accelerate the growth and development.However,few research on bovine T1Rs receptors could be found.Therefore,it is essential for us to review the progress of T1Rs receptors.This paper reviews recent advances on the structure-function relationships of T1R receptors and signaling transduction mechanism from sweet taste and umami taste. |
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| Keywords: | T1Rs Signaling transduction Sweet taste Umami taste |
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