| 人工合成精氨酸双糖苷AFG的急性毒性实验 |
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| 引用本文： | 齐晶华,郑毅男,刘文丛.人工合成精氨酸双糖苷AFG的急性毒性实验[J].人参研究,2013,25(2):39-40. |
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| 作者姓名： | 齐晶华 郑毅男 刘文丛 |
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| 作者单位： | 吉林农业大学中药材学院 吉林长春·130118 |
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| 摘 要： | 目的研究人工合成精氨酸双糖苷AFG的急性毒性作用。方法将人工合成精氨酸双糖苷AFG以最大浓度和最大给药体积给KM小鼠灌胃给药。观察7d内小鼠的毒性反应以及死亡情况。结果小鼠未出现死亡情况，未测出LD50，测得其最大耐受量为6g／kg，与成人日用人参量3-9g相比，相当于成人人参日用量的4-13倍。结论人工合成精氨酸双糖苷AFG无急性毒性作用，具有较好的安全性。
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| 关 键 词： | 人工合成精氨酸双糖苷AFG 急性毒性试验 灌胃给药 最大耐受量 |
Actue Toxicity Test of Argininyl-fructoyl-glucose(AFG) |
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| Authors: | QI Jing-hua ZHENG yi-nan LIU wen-cong |
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| Institution: | (Jilin Agricultural science and technology college,plant science of college ) |
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| Abstract: | Objective To observe the actue toxicity test of Argininyl-fructoul-glucose in mice.Methods：Use Argininyl-fructoul-glucose with the maximum concentration, the maximum volume of mice a drug to fill the stomach,observed in the 7 d mice toxicity and death.Results：All mice survived,the LD50 unforeseen measured,the Maximum tolerated dosage was 6g/kg,compared with adult daily ginseng 3 - 9g, which is equivalent to the adult clinical dose of 4-13 times.Conclusion：AFG had no obviously the acute toxicity in mice,and AFG has better security. |
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| Keywords: | Argininyl-fructoul-glucose Acute toxicity Maximum tolerated dosage |
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