Long-term complete chimerism and stable hematopoiesis in beagles after fetal liver hematopoietic stem cell transplantation |
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| Authors: | G R Cain R E Champlin |
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| Affiliation: | Laboratory for Energy-Related Health Research, University of California, Davis 95616. |
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| Abstract: | Karyotype analysis of bone marrow cells was performed from 6 Beagles that had received sex-mismatched fetal liver hematopoietic stem cell grafts 2.4 to 6.5 years earlier. Two dogs received dog leukocyte antigen-matched fetal liver cells and 4 received dog leukocyte antigen-mismatched cells. In each dog, all 25 evaluated metaphase spreads were of donor genotype. All dogs had normal hemograms and repopulation of bone marrow and no dog developed graft-vs-host disease. |
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