Renal biomarkers in cats: A review of the current status in chronic kidney disease |
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| Authors: | Thirawut Kongtasai Dominique Paepe Evelyne Meyer Femke Mortier Sofie Marynissen Lisa Stammeleer Pieter Defauw Sylvie Daminet |
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| Institution: | 1. Small Animal Department, Faculty of Veterinary Science, Ghent University, Merelbeke Belgium ; 2. Department of Clinical Sciences and Public Health, Faculty of Veterinary Science, Mahidol University, Nakhon Pathom Thailand ; 3. Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, Merelbeke Belgium ; 4. Lumbry Park Veterinary Specialists, Alton United Kingdom |
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| Abstract: | Serum creatinine concentration, the classical biomarker of chronic kidney disease (CKD) in cats, has important limitations that decrease its value as a biomarker of early CKD. Recently, serum symmetric dimethylarginine concentration was introduced as a novel glomerular filtration rate biomarker for the early detection of CKD in cats. However, data on its specificity are still limited. The limitations of conventional biomarkers and the desire for early therapeutic intervention in cats with CKD to improve outcomes have prompted the discovery and validation of novel renal biomarkers to detect glomerular or tubular dysfunction. Changes in the serum or urinary concentrations of these biomarkers may indicate early kidney damage or predict the progression of kidney before changes in conventional biomarkers are detectable. This review summarizes current knowledge on renal biomarkers in CKD in cats, a field that has progressed substantially over the last 5 years. |
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| Keywords: | feline fibroblast growth factor‐ 23 kidney injury molecule‐ 1 liver‐ type fatty acid‐ binding protein neutrophil gelatinase‐ associated lipocalin transforming growth factor‐ β 1 |
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