| 中药单体化合物光甘草定的体外抗菌活性研究 |
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| 引用本文： | 赵全民,于录,邓旭明,王春雨,王全凯.中药单体化合物光甘草定的体外抗菌活性研究[J].中国预防兽医学报,2010,32(3). |
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| 作者姓名： | 赵全民 于录 邓旭明 王春雨 王全凯 |
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| 作者单位： | 1. 吉林农业大学人兽共患病教育部重点实验室,吉林,长春130118
2. 吉林大学人兽共患病研究所,吉林,长春130062 |
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| 基金项目： | 国家重点基础研究发展计划(973计划) |
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| 摘 要： | 选取传统中药甘草提取单体化合物光甘草定,通过MABA药物敏感性实验方法研究其对结核分枝杆菌H37Rv(ATCC27294)和H37Ra(ATCC25177)的体外抗菌活性,并通过NCCLS标准方法测定了光甘草定对金黄色葡萄球菌ATCC25923和ATCC29213、粪肠球菌ATCC29212和大肠杆菌ATCC25922的最低抑菌浓度(MIC)。结果表明:单体化合物光甘草定对结核分枝杆菌H37Rv(ATCC27294)和H37Ra(ATCC25177)有很好的抗菌活性,最低抑菌浓度均为25μg/m;光甘草定对实验中检测的金黄色葡萄球菌、粪肠球菌和大肠杆菌也有抗菌活性,并且对革兰氏阳性杆菌的抗菌活性高于革兰氏阴性杆菌。本研究为光甘草定的进一步开发利用和抗菌机制研究打下了基础。
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| 关 键 词： | 光甘草定 结核分枝杆菌 敏感性 最低抑菌浓度 活性 |
Antimycobacterial and antibacterial activity of glabridin from Glycyrrhiza uralensis Flsch in vitro |
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| ZHAO Quan-min,YU Lu,DENG Xu-ming,WANG Chun-yu,WANG Quan-kai.Antimycobacterial and antibacterial activity of glabridin from Glycyrrhiza uralensis Flsch in vitro[J].Chinese Journal of Preventive Veterinary Medicine,2010,32(3). |
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| Authors: | ZHAO Quan-min YU Lu DENG Xu-ming WANG Chun-yu WANG Quan-kai |
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| Institution: | ZHAO Quan-min1,YU Lu2,DENG Xu-ming2,WANG Chun-yu1,WANG Quan-kai1 (1. Jilin Agricultural University,Changchun 130118,China,2. Key Laboratory of Zoonosis,Ministry of Education,Institute of Zoonosis,Jilin University,Changchun 130062,China) |
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| Abstract: | Glabridin is an active flavonoid constituent from Glycyrrhiza uralensis Flsch,a traditional Chinese medicine. The antimycobacterial susceptibility of glabridin was determined by a microdilution alamar blue Assay (MABA) against Mycobacterium tuberculosis H37Rv (ATCC 27294) and H37Ra (ATCC 25177),and the antibacterial activities were determined by broth microdilution against Staphylococcus aureus ATCC25923 and ATCC29213,Enterococcus faecalis ATCC29212,and Escherichia coli ATCC25922. The results showed that gl... |
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| Keywords: | glabridin Mycobactcrium tuberculosis minimal inhibitory concentration |
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