Histocompatible embryonic stem cells by parthenogenesis |
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| Authors: | Kim Kitai Lerou Paul Yabuuchi Akiko Lengerke Claudia Ng Kitwa West Jason Kirby Andrew Daly Mark J Daley George Q |
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| Affiliation: | Division of Pediatric Hematology/Oncology, Children's Hospital Boston and Dana Farber Cancer Institute, Boston, MA 02115, USA. |
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| Abstract: | Genetically matched pluripotent embryonic stem (ES) cells generated via nuclear transfer or parthenogenesis (pES cells) are a potential source of histocompatible cells and tissues for transplantation. After parthenogenetic activation of murine oocytes and interruption of meiosis I or II, we isolated and genotyped pES cells and characterized those that carried the full complement of major histocompatibility complex (MHC) antigens of the oocyte donor. Differentiated tissues from these pES cells engrafted in immunocompetent MHC-matched mouse recipients, demonstrating that selected pES cells can serve as a source of histocompatible tissues for transplantation. |
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