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Immunologic and genetic characterization of S180, a cell line of murine origin capable of growing in different inbred strains of mice
Authors:G Alfaro  C Lomeli  R Ocadiz  V Ortega  R Barrera  M Ramirez and G Nava
Institution:

a Departamento de Inmunologia, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, 04510, Mexico D.F., Mexico

b Division de Investigacion Basica, Instituto Nacional de Cancerologia, 14000, Mexico D.F., Mexico

Abstract:Some of the immunologic and genetic properties of the cell line S180 have been examined. These cells grew without restrictions in the peritoneal cavity of different inbred strains of mice and invariably killed the animals. With Northern blots it was demonstrated that S180 cells contained class I mRNAs but failed to transcribe B2m genes. However, under experimental conditions, a protective humoral immune response mediated by cytotoxic antibodies and complement against S180 cells was obtained through non-H-2 antigens in C57BL/6J mice.
Keywords:
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