Microfluidic large-scale integration |
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Authors: | Thorsen Todd Maerkl Sebastian J Quake Stephen R |
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Institution: | Biochemistry and Molecular Biophysics Option, Department of Applied Physics, California Institute of Technology, Pasadena, CA 91125, USA. |
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Abstract: | We developed high-density microfluidic chips that contain plumbing networks with thousands of micromechanical valves and hundreds of individually addressable chambers. These fluidic devices are analogous to electronic integrated circuits fabricated using large-scale integration. A key component of these networks is the fluidic multiplexor, which is a combinatorial array of binary valve patterns that exponentially increases the processing power of a network by allowing complex fluid manipulations with a minimal number of inputs. We used these integrated microfluidic networks to construct the microfluidic analog of a comparator array and a microfluidic memory storage device whose behavior resembles random-access memory. |
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