Lymphotoxin is an important T cell-derived growth factor for human B cells |
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| Authors: | J H Kehrl M Alvarez-Mon G A Delsing A S Fauci |
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| Institution: | Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892. |
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| Abstract: | Two different assays for B cell growth factors (BCGF) and an antibody against lymphotoxin were used to show that the presence of lymphotoxin in conditioned media derived from normal activated T cells and in a partially purified BCGF accounts for a substantial portion of their B cell growth-promoting activity. A competitive binding assay confirmed the presence of significant amounts of lymphotoxin in the partially purified BCGF. Recombinant lymphotoxin enhanced the proliferation of activated B cells and augmented B cell proliferation and immunoglobulin secretion induced by interleukin-2. |
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