Comment on "PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation" |
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| Authors: | Gruber Thomas Freeley Michael Thuille Nikolaus Heit Isabelle Shaw Stephen Long Aideen Baier Gottfried |
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| Institution: | Department for Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Austria. |
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| Abstract: | We observe that protein kinase C (PKC) is phosphorylated on the activation loop at threonine 538 (Thr-538) before T cell activation. Our results are inconsistent with the conclusions of Lee et al. (Reports, 1 April 2005, p. 114) that the Thr-538 phosphorylation of PKC is regulated by T cell receptor activation. Other mechanisms, such as autophosphorylation of Thr-219, might orchestrate the cellular function of PKC in T cells. |
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