Effect of thyrotropin releasing hormone (TRH) on serum levels of thyroid hormones in thoroughbred mares |
| |
| Authors: | C.L. Chen DVM PhD W.I. Li DVM MS |
| |
| Affiliation: | 1. Superior School of Health Sciences, Amazonas State University − UEA, Manaus, Amazonas, Brazil;2. Medical School, Amazonas Federal University − UFAM, and Medical School, Nilton Lins University − UNL, Manaus, Amazonas, Brazil;3. Department of Internal Medicine, Botucatu Medical School, Sao Paulo State University − UNESP, Botucatu, Sao Paulo, Brazil;1. ISISE, Department of Civil Engineering, University of Coimbra, 3030-790 Coimbra, Portugal;2. Department of Structures for Engineering and Architecture, University of “Federico II” of Naples, 80134 Naples, Italy;3. Faculty of Engineering, State University of Rio de Janeiro, Maracanã, 20550-013 Rio de Janeiro, Brazil;1. Division of Prevention and Rehabilitation, University of Ottawa Heart Institute, Ottawa, Ontario, Canada;2. Faculty of Health Sciences, School of Human Kinetics, University of Ottawa, Ottawa, Ontario, Canada |
| |
| Abstract: | Effects of thyrotropin releasing hormone (TRH) on serum levels of thyroid hormones were studied in 12 Thoroughbred mares. Significant increases (P<0.05) of serum T4 levels occurred as early as 2 hours and peaked at 4–10 hours after intravenous injection of 0.5 – 5 mg TRH. Following injection of 0.5, 1, 3 and 5 mg of TRH the serum levels of T4 were increased 2.25, 2.42,2.42 and 3.67 fold, respectively, over pre-injection levels. Serum levels of T3 were also significantly increased (P<0.05) at 1 or 2 hours and peaked at 2 to 4 hoursafter injection. The mean peak increase of T3 levels were 2.87, 3.21, 3.10 and 3.10 fold over pre- injected in level in 0.5, 1, 3,5 mg treated horses, respectively. These results suggest that TRH can be an alternative to heterologous TSH for the equine thyroid function test. The recommended dosage is 1–3 mg, and most appropriate time to collect post-TRH blood sample is between 4–6 hours. Serum levels of T4 and T3 should increase 2–3 fold from baseline in normal horses. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
