New Perspectives in the Chemistry of Marine Pyridoacridine Alkaloids |
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Authors: | Alois Plodek Franz Bracher |
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Institution: | Department of Pharmacy—Center for Drug Research, Ludwig-Maximilians University, Butenandtstr. 5-13, 81377 Munich, Germany; |
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Abstract: | Secondary metabolites from marine organisms are a rich source of novel leads for drug development. Among these natural products, polycyclic aromatic alkaloids of the pyridoacridine type have attracted the highest attention as lead compounds for the development of novel anti-cancer and anti-infective drugs. Numerous sophisticated total syntheses of pyridoacridine alkaloids have been worked out, and many of them have also been extended to the synthesis of libraries of analogues of the alkaloids. This review summarizes the progress in the chemistry of pyridoacridine alkaloids that was made in the last one-and-a-half decades. |
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Keywords: | marine alkaloids pyridoacridines total synthesis |
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