Yessotoxin,a Promising Therapeutic Tool |
| |
| Authors: | Amparo Alfonso Mercedes R. Vieytes Luis M. Botana |
| |
| Affiliation: | 1Department of Pharmacology, Faculty of Veterinary, University of Santiago of Compostela, 27002 Lugo, Spain;2Department of Physiology, Faculty of Veterinary, University of Santiago of Compostela, 27002 Lugo, Spain; |
| |
| Abstract: | Yessotoxin (YTX) is a polyether compound produced by dinoflagellates and accumulated in filter feeding shellfish. No records about human intoxications induced by this compound have been published, however it is considered a toxin. Modifications in second messenger levels, protein levels, immune cells, cytoskeleton or activation of different cellular death types have been published as consequence of YTX exposure. This review summarizes the main intracellular pathways modulated by YTX and their pharmacological and therapeutic implications. |
| |
| Keywords: | yessotoxin (YTX) apoptosis autophagy cellular death signal transduction cytoskeleton immune system Alzheimer glucose metabolism |
|
|
