|
|||||
|
|
| Research Progress on Production of Podophyllotoxin from Sinopodophyllum hexandrum | |
| 作者姓名： | LiuHaijun XuYan SuGuoqing LiChunyan WangLi LiuYujun |
| 作者单位： | [1]CollegeofBiologicalSciencesandBiotechnology,BeijingForestryUniversity,Beijing100083,P.R.China [2]CollegeofLandscapeArchitecture,BeijingForestryUniversity,Beijing100083,P.R.China [3]ForestryDepartment,TibetAgricultureandAnimalHusbandryCollege,Linzhi860000,P.R.China |
| 摘 要： | Podophyllotoxin is isolated mainly from the rhizomes of Podophyllum plants, and serves as the main precursor for synthesis of anticancer drugs, such as VP-16 and VM-26. VP-16 and VM-26 are used for curing lung cancer, testicular cancer,neuroblastoma, hepatoma and other tumors. However, these plants are all near-extinction species due to over-collection and their own biological characteristics. The chemical synthesis of podophyllotoxin is so complicated that its price is unbelievably high.This paper discusses the current status of the biosynthetic pathway of podophyllotoxin and that of the podophyllotoxin production using several biotechnological approaches such as plant organ cultures, plant cell cultures with both flasks and bioreactors, hairy root cultures, bioconversions and metabolic regulations. |
| 关 键 词： | 鬼臼毒素 中国鬼臼属 植物 细胞培养 须根 |
| 收稿时间： | 2003-9-3 |
Research Progress on Production of Podophyllotoxin from Sinopodophyllum hexandrum |
|
| LiuHaijun XuYan SuGuoqing LiChunyan WangLi LiuYujun.Research Progress on Production of Podophyllotoxin from Sinopodophyllum hexandrum[J].Forestry Studies in China,2004,6(1):48-53. | |
| Authors: | Liu Haijun Xu Yan Su Guoqing LI Chunyan Wang Li Liu Yujun |
| Institution: | 1. College of Biological Sciences and Biotechnology, Beijing Forestry University, Beijing 100083, P. R. China 2. College of Landscape Architecture, Beijing Forestry University, Beijing 100083, P. R. China 3. Forestry Department, Tibet Agriculture and Animal Husbandry College, Linzhi 860000, P. R. China 4. College of Biological Sciences and Biotechnology, Beijing Forestry University, Beijing 100083, P. R. China;Forestry Department, Tibet Agriculture and Animal Husbandry College, Linzhi 860000, P. R. China |
| Abstract: | Podophyllotoxin is isolated mainly from the rhizomes of Podophyllum plants, and serves as the main precursor for synthesis of anticancer drugs, such as VP-16 and VM-26. VP-16 and VM-26 are used for curing lung cancer, testicular cancer, neuroblastoma, hepatoma and other tumors. However, these plants are all near-extinction species due to over-collection and their own biological characteristics. The chemical synthesis of podophyllotoxin is so complicated that its price is unbelievably high. This paper discusses the current status of the biosynthetic pathway of podophyllotoxin and that of the podophyllotoxin production using several biotechnological approaches such as plant organ cultures, plant cell cultures with both flasks and bioreactors, hairy root cultures, bioconversions and metabolic regulations. |
| Keywords: | podophyllotoxin Sinopodophyllum hexandrum plant cell culture hairy root culture biosynthesis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |
| 点击此处可从《中国林学》浏览原始摘要信息 | |
| 点击此处可从《中国林学》下载免费的PDF全文 | |