Efficacy of moxidectin 1% injectable against natural infection of Sarcoptes scabiei in sheep. |
| |
Authors: | M R Hidalgo Argüello N Díez-Ba?os B Martínez-González F A Rojo-Vázquez |
| |
Institution: | Departamento de Patología Animal (Sanidad Animal), Facultad de Veterinaria, Campus de Vegazana, Universidad de León, 24071 León, Spain. dsamha@isidoro.unileon.es |
| |
Abstract: | Thirty ewes naturally infected with Sarcoptes scabiei var. ovis, were allocated into three groups of 10 animals each. Animals in groups B and C were treated on day 0 and on days 0 and +10, respectively, with moxidectin 1% injectable at a dose of 0.2mg moxidectin/kg body weight (BW). Group A remained untreated. Seven days before treatment, the geometric mean of Sarcoptes scabiei var. ovis per square centimeter of skin in groups A, B and C were not significantly different. From the day of treatment to the end of the trial, the average number of mites/cm(2) increased in untreated animals and decreased in groups B and C, but these values were higher for group C. Active lesions produced by S. scabiei var. ovis consistently increased during the trial in the untreated animals; in group B the minimum count occurred on day +56 this reduction being more evident in group C (no lesions on days +49 and +56). Also in this group, the number of cured animals was 100%, therefore, the application of two treatments with moxidectin (group C) showed higher efficacy than a single treatment (group B). Body condition score decreased in the three experimental groups along the trial. All animals were individually weighed on days -1, +28 and at the end of the trial. No adverse reactions were observed in the animals treated with 0.2mg moxidectin/kg BW. |
| |
Keywords: | |
|
|