广藿香不同软化方法比较及炮制工艺优化

目的]优选广藿香的最佳炮制工艺,并应用于实际生产中。方法]采用汽相置换式润药机,分别考察广藿香茎和叶的炮制工艺。以炮制品的性状、醇溶性浸出物得率、百秋李醇含量为指标,采用单因素试验优选出茎的最佳软化方法,然后采用正交设计试验L_9(3~4),考察切段长度、干燥温度和干燥时间等因素对茎炮制工艺的影响。以水分、百秋李醇和挥发油含量为指标,优选叶的最佳炮制工艺。结果]广藿香茎的最佳炮制工艺:茎抢水清洗1次,置真空汽相置换润药中50℃润制2.0 h,取出后,切制成段(4 mm左右),再于50℃干燥1.5 h。叶的最佳炮制工艺:叶抢水清洗1次,置50℃干燥135 min。结论]经过工艺验证可知,该工艺稳定可靠,确定的广藿香炮制工艺可用于实际生产。

Comparison of Different Softening Methods for Patchouli and Optimization of Processing Technology

Objective] To optimize the best processing technology of patchouli,and determine the process parameters for the application of the actual production.Method] Separate investigation on processing technology of patchouli stems and leaves was conducted by vapor phase displacement type medicine moistening machine.With the characters of processed products,alcohol soluble extract yield and content of patchouli alcohol as indexes,the optimal processing technology of patchouli stems were obtained using single factor experiment.Then using orthogonal design L9 (34) to study the effects of cutting length,drying temperature and drying time on the processing technology of patchouli stems.With the content of the water,patchouli alcohol and volatile oil as indexes,processing technology of leaves was optimized.Result] The optimal processing technology of patchouli stems:The stem is washed once in water,put the patchouli to the vacuum vapor replacement,and set as 50℃ run 2 h,then remove,and cut into sections (about 4mm),and then dry 1.5 h at 50℃.The optimal processing technology of patchouli leaves:The leave is washed once in water,and then dry 135 min at 50℃.Conclusion] After the process validation,it is stable and reliable.The processing technology of patchouli prepared by the method can be used in practical production.