The effect of induced fever on the biokinetics of norfloxacin and its interaction with probenecid in goats |
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Authors: | K Jha B K Roy R C P Singh |
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Institution: | (1) Department of Pharmacology and Toxicology, Ranchi Veterinary College, 834007 Ranchi, India;(2) Deputy Registrar, Birsa Agricultural University, 834006 Ranchi, India |
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Abstract: | The kinetic profiles of norfloxacin were evaluated in afebrile, febrile and probenecid pre-treated (70 mg/kg orally) febrile goats after a single intravenous (i.v) dose (5 mg/kg). Fever was induced and maintained for 12 h by injecting Escherichia coli endotoxin (0.2 g/kg, i.v.) and repeating it in half the dose (0.1 g/kg) 5 h later. The plasma pharmacokinetic values for norfloxacin were best represented using a two-compartment open model. The peak norfloxacin plasma level of 90.52±3.18 g/ml attained in the probenecid pre-treated febrile goats was higher than that in the febrile (75.46±0.72 g/ml) or afebrile goats (62.25±1.23 g/ml). ClB and K
el values were significantly (p<0.01) decreased in febrile compared with afebrile goats. These values were further reduced in febrile goats after probenecid pre-treatment. However, t
1/2 was not affected by the fever-probenecid interaction. Norfloxacin may be used as an infusion with probenecid in caprine diseases where very high plasma levels are required to combat resistant organisms such as Bacteroides.Abbreviations MIC
minimum inhibitory concentration
- LPS
lipopolysaccharide
- i.v.
intravenous(ly) |
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Keywords: | fever fluoroquinolone goat norfloxacin pharmacokinetics probenecid |
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