| 含硫香料化合物3-甲硫基-1-己醇及其乙酸酯的合成研究 |
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| 引用本文： | 郭安齐. 含硫香料化合物3-甲硫基-1-己醇及其乙酸酯的合成研究[J]. 郑州牧业工程高等专科学校学报, 2009, 29(3): 10-12 |
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| 作者姓名： | 郭安齐 |
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| 作者单位： | 河南职工医学院,河南,郑州,450003 |
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| 摘 要： | 本文以E-2-己烯醛为原料研究了3-甲硫基己醇及3-甲硫基乙酸己酯的合成方法。首先甲硫醇钠与E-2-己烯醛发生1,4-共轭加成得到3-甲硫基己醛,产率87%;然后用硼氢化钠还原得到3-甲硫基己醇,产率92%左右;3-甲硫基己醇在乙酸钠的催化下与乙酸酐反应,得到3-甲硫基乙酸己酯,产率约95%。产物结构经过GC/MS和1HNMR谱图进行了确认。
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| 关 键 词： | 含硫香料 3-甲硫基-1-己醇 3-甲硫基乙酸己酯 合成 |
Study on Syntheses of Sulfur-containing Flavors 3-Methylthio-1-hexanol and 3-Methylthio-1-hexyl Acetate |
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| GUO An-qi. Study on Syntheses of Sulfur-containing Flavors 3-Methylthio-1-hexanol and 3-Methylthio-1-hexyl Acetate[J]. Journal of Zhengzhou College of Animal Husbandry Engineering, 2009, 29(3): 10-12 |
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| Authors: | GUO An-qi |
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| Affiliation: | GUO An-qi (Henan Medical College for Staff and Workers, Zhengzhou 450003, China) |
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| Abstract: | The Syntheses of sulfur- containing flavors 3 - methylthio- 1 - hexanol and 3 - methylthio- 1 - hexyl ace- tate were studied by starting from E-2-hexenal. The 1,4-conjugated addition of sodium thiomethoxide with E-2- hexenal gave 3-methylthio hexanal in about 87% yield; 3--methylthio hexanal was reduced by NaBH4 to produce 3- methylthio hexanol in about 92% 3-methylthio hexyl acetate was obtained by esterification of 3-methylthio hexanol with acetic anhydride catalyzed by sodium acetate in about 95% yield. The products were confirmed by GC/MS and 1 H NMR. |
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| Keywords: | Sulfur- containing flavors 3 - methylthio- 1 - hexanol 3 - methylthio- 1 - hexyl acetate synthesis |
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