| 吡喹酮缓释剂治疗小鼠日本血吸虫病的试验 |
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| 引用本文： | 叶萍,董克难.吡喹酮缓释剂治疗小鼠日本血吸虫病的试验[J].中国兽医寄生虫病,1997,5(4):4-6. |
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| 作者姓名： | 叶萍 董克难 |
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| 作者单位： | 中国农科院上海家畜寄生虫病研究所!200232(叶萍，陈永军，李浩，石耀军，傅志强，施福恢)，烟台市进出口商品检验局(董克难)，青岛市进出口商品检验局(李伟才) |
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| 摘 要： | 为了观察吡喹酮缓释剂治疗小鼠日本血吸虫病的效果，本试验以可生物降解的壳聚糖作为高分子包裹材料，制备吡喹酮缓释剂（包封率为56．05％），通过皮下埋植治疗人工感染日本血吸虫尾蚴（60±1条）40d后的ICR小鼠，4周后剖杀小鼠。结果，吡喹酮剂量138．4mg／kg的治疗组减虫率为64．08％（P＜0．01），减雌率75．86％（P＜0．001）；吡喹酮剂量69．2mg／kg治疗组的减虫率为25．29％（P＞0．05），减雌率39．14％（P＞0．05）。毒性试验组小鼠皮下埋植空白壳聚糖微囊后，未见小鼠出现中毒症状和死亡。
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| 关 键 词： | 吡喹酮缓释剂 小鼠日本血吸虫病 壳聚糖 |
STUDY ON SLOW RELEASED PRAZIQUANTEL TREATING MURINE SCHISTOSOMIASIS JAPONICA |
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| Ye Ping,Chen Yongjun,Li Hao,Shi Yaojun,Fu Zhiqiang,Shi Fuhui.STUDY ON SLOW RELEASED PRAZIQUANTEL TREATING MURINE SCHISTOSOMIASIS JAPONICA[J].Chinese Journal of Veterinary Parasitology,1997,5(4):4-6. |
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| Authors: | Ye Ping Chen Yongjun Li Hao Shi Yaojun Fu Zhiqiang Shi Fuhui |
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| Abstract: | In order to observe the effection of slow released praziquantel (SRP) treating murine Schistosomiasis japonicum, we use chitin, a kind of biodecreased nutural polymer, to pack praziquantel (packing rate is 56.05%), then obtain a slow released praziquantel. 21 ICR mice were challenged with schistosoma joponicum, 60 cercariae for each. 40 days after challenging, group 1 and 2(7 mice for each) were subcutaneously embed with slow released praziquantel. 4 week later, autopsy all mice. The results are as follows:Group 1 (the dosage of SRP is 138.4 mg/kg) gained 64.08% (p<0.01) worm reduction rate and 75.86% (p<0.001) female worm reduction rate. Group 2 (the dosage of SRP is 69.2 mg/kg), gained 25.29 % (P>0.05) worm reduction rate and 39.14 % (P>0.05) female worm reduction rate. No toxic symptom was found in the group of toxic test and no mouse dead in toxin. |
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| Keywords: | Slow released praziquantel Schistosomiasis japonica chitin |
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