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The effect of omeprazole on oesophageal pH in dogs during anaesthesia |
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| Authors: | A Panti RC Bennett F Corletto J Brearley N Jeffrey and RJ Mellanby |
| Institution: | University of Cambridge, Department of Veterinary Medicine, Madingley Road, Cambridge CB3 0ES; Newmarket Equine Hospital, Cambridge Road, Newmarket CB8 0FG; Dick White Referrals, Station Farm, London Road, Six Mile Bottom, Suffolk CB8 0UH; Royal (Dick) School of Veterinary Studies, The Roslin Institute, Division of Veterinary Clinical Studies, The University of Edinburgh, Hospital for Small Animals, Easter Bush Veterinary Centre, Roslin, Midlothian EH25 9RG |
| Abstract: | O bjectives : Intra-operative, gastro-oesophageal reflux may be associated with post-anaesthestic complications such as oesophagitis and oesophageal stricture in dogs. The aim of this study was to investigate the effect of preoperative administration of omeprazole, a proton pump inhibitor, on oesophageal pH in anaesthetised dogs. M ethods : Forty-seven dogs undergoing elective pelvic limb orthopaedic surgery were enrolled into the study. These were randomly allocated to treatment group (n=22) or control group (n=25). The treatment group received one dose of omeprazole (1 mg/kg po) at least 4 h before anaesthesia. All dogs were anaesthetised by the same standardised protocol. A pH probe was inserted into the distal oesophagus after induction of anaesthesia and oesophageal pH was continuously monitored. R esults : In the treatment group, four animals (18 per cent) showed a sudden decrease in oesophageal pH (<4). In the control group the same phenomenon was detected in 13 animals (52 per cent). Gastro-oesophageal reflux occurred more frequently in the control group compared with the omeprazole group (odds ratio 4·7, 95 per cent C.I. 1.1 to 24.7, P=0.032). C linical S ignificance : This study suggests that the preoperative administration of omeprazole is effective in reducing the incidence of gastro-oesophageal reflux during anaesthesia in dogs. |
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