| 兽用喹噁啉类遗传毒性研究进展 |
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| 引用本文： | 王旭. 兽用喹噁啉类遗传毒性研究进展[J]. 中国兽药杂志, 2013, 47(5): 62-65 |
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| 作者姓名： | 王旭 |
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| 作者单位： | 国家兽药残留基准实验室(华中农业大学)/农业部兽药残留检测重点实验室,武汉,430070 |
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| 基金项目： | 国家重点基础研究发展计划(973)项目(NO.2009CB118800) |
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| 摘 要： | 综述了卡巴氧、喹乙醇、乙酰甲喹、喹烯酮、喹赛多等兽用喹噁啉类药物遗传毒性的研究进展,为此类药物在临床上的合理应用及毒性机制的深入研究提供参考.而此类药物主要代谢物的遗传毒性检测、代谢过程中自由基的产生、DNA修复酶活性变化、线粒体损伤程度等方面的研究,将有助于全面深入地揭示该类化合物的遗传毒性.
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| 关 键 词： | 喹噁啉类化合物 遗传毒性 兽药 |
| 收稿时间： | 2013-01-07 |
| 修稿时间： | 2013-03-21 |
Progress of Study on the Genetic Toxicity of Quinoxaline 1,4-Dioxides |
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| WANG Xu , TAN Zi-qiang , HUANG Ling-li , LIU Zhen-li , YUAN Zong-hui. Progress of Study on the Genetic Toxicity of Quinoxaline 1,4-Dioxides[J]. Chinese Journal of Veterinary Drug, 2013, 47(5): 62-65 |
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| Authors: | WANG Xu TAN Zi-qiang HUANG Ling-li LIU Zhen-li YUAN Zong-hui |
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| Affiliation: | National Reference Laboratory of Veterinary Drug Residues (HZAU) and Ministry of Agriculture Key Laboratory for the Detection of Veterinary Drug Residues in Foods |
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| Abstract: | The genetic toxicity of quinoxaline 1, 4-dioxides (QdNOs) such as carbadox, olaquindox, mequindox, cyadox and quinocetone are reviewed in order to provide reference for its rational application and further research on genotoxicity mechanism. It will help to deeply reveal the genotoxicity mechanism of QdNOs in research on their genetic toxic metabolites, the free radicals produced during the metabolic process, the inhibition of DNA repair enzymes and mitochondrial damage. |
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