Mansouramycins E–G,Cytotoxic Isoquinolinequinones from Marine Streptomycetes |
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| Authors: | Mohamed Shaaban Khaled A Shaaban Gerhard Kelter Heinz Herbert Fiebig Hartmut Laatsch |
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| Institution: | 1.Institute of Organic and Biomolecular Chemistry, University of Göttingen, Tammannstrasse 2, D-37077 Göttingen, Germany or (M.S.); (K.A.S.);2.National Research Centre, Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Institute, El-Behoos St. 33, Giza 12622, Egypt;3.Oncotest GmbH, Charles River Discovery Germany, Am Flughafen 14, D-79108 Freiburg, Germany;4.Oncotest GmbH, Biotec GmbH, Am Flughafen 14, D-79108 Freiburg, Germany; |
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| Abstract: | Chemical investigation of the ethyl acetate extract from the marine-derived Streptomyces sp. isolate B1848 resulted in three new isoquinolinequinone derivatives, the mansouramycins E–G (1a–3a), in addition to the previously reported mansouramycins A (5) and D (6). Their structures were elucidated by computer-assisted interpretation of 1D and 2D NMR spectra, high-resolution mass spectrometry, and by comparison with related compounds. Cytotoxicity profiling of the mansouramycins in a panel of up to 36 tumor cell lines indicated a significant cytotoxicity and good tumor selectivity for mansouramycin F (2a), while the activity profile of E (1a) was less attractive. |
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| Keywords: | mansouramycins isoquinolinequinones marine-derived Streptomyces sp cytotoxicity |
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